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Protection of Mice against Coccidioides immitis Intranasal Infection by Vaccination with Recombinant Antigen 2/PRA

机译：通过接种重组抗原2 / PRA预防小鼠对球虫的炎性鼻内感染。

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摘要

Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

机译：重组抗原2 / PRA（rAg2 / PRA）的皮下疫苗接种可保护BALB / c小鼠免于鼻内感染球虫球菌性炎。皮下接种的C57BL / 6小鼠和鼻内接种的BALB / c小鼠受到保护，可以抵抗大量的感染孢子。体重减轻与致死率相关，但组织学外观无相关性。这些研究支持rAg2 / PRA疫苗接种以预防球虫球菌病。

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Shubitz, Lisa; Peng, Tao; Perrill, Robert; Simons, Julie; Orsborn, Kris; Galgiani, John N;
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年度 2002
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正文语种 en
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专利

1. Localization within a Proline-Rich Antigen (Ag2/PRA) of Protective Antigenicity against Infection with Coccidioides immitis in Mice [J] . Tao Peng, Lisa Shubitz, Julie Simons, Infection and immunity . 2002,第7期

机译：脯氨酸丰富抗原（Ag2 / PRA）在小鼠中对球虫球菌性炎性感染的保护性抗原性的本地化。
2. Genetic Vaccination against Coccidioides immitis: Comparison of Vaccine Efficacy of Recombinant Antigen 2 and Antigen 2 cDNA [J] . Chengyong Jiang, D. Mitchell Magee, Teresa N. Quitugua, Infection and immunity . 1999,第2期

机译：预防球虫免疫的基因疫苗：重组抗原2和抗原2 cDNA疫苗效力的比较。
3. Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein [J] . Shubitz LF, Yu JJ, Hung CY, Vaccine . 2006,第31a32期

机译：使用表达为单一蛋白质的两种重组抗原，提高了小鼠抗致命性球孢子虫呼吸道感染的保护能力
4. Intranasal vaccination of mannan-decorated mucoadhesive HPMCP microspheres containing ApxIIA toxin effectively protected Actinobacillus pleuropneumoiaeinfection in mice [C] . Hui-Shan Li, Min-Kyoung Shin, Bijay Singh, World biomaterials congress . 2016

机译：含ApxIIA毒素的甘露聚糖修饰的粘膜粘附HPMCP微球的鼻内疫苗接种可有效保护小鼠胸膜肺炎放线杆菌感染
5. Correlates of protection in response to mucosal vaccination with uropathogenic Escherichia coli antigens and the role of IL-17A during urinary tract infection. [D] . Sivick, Kelsey Elizabeth. 2010

机译：与泌尿致病性大肠杆菌抗原的粘膜疫苗接种反应相关的保护作用和尿道感染期间IL-17A的作用。
6. Protection of Mice against Coccidioides immitis Intranasal Infection by Vaccination with Recombinant Antigen 2/PRA [O] . Lisa Shubitz, Tao Peng, Robert Perrill, 2002

机译：通过接种重组抗原2 / PRA预防小鼠对球虫的炎性鼻内感染。
7. Localization within a Proline-Rich Antigen (Ag2/PRA) of Protective Antigenicity against Infection with Coccidioides immitis in Mice [O] . Peng, Tao, Shubitz, Lisa, Simons, Julie, 2002

机译：脯氨酸丰富抗原（Ag2 / PRA）在小鼠体内对球虫球菌性炎性感染的保护性抗原性的本地化。

Protection of Mice against Coccidioides immitis Intranasal Infection by Vaccination with Recombinant Antigen 2/PRA

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